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Jun yu loo12/3/2023 ![]() Human Proteinpedia enables sharing of human protein data. Mass Spectrometry of Protein Assemblies NIH R01RR020004 Jul 15, 2004 - Role: Principal Investigator Mass Spectrometry of Protein Assemblies NIH R01GM103479 Jul 15, 2004 - Role: Principal Investigator High Resolution Hybrid FT-ICR Mass Spectrometer NIH S10RR023045 Aug 1, 2006 - Role: Principal Investigator Top-Down Mass Spectrometry of Salivary Fluids for Cancer Assessment NIH R21CA126106 Sep 26, 2006 - Role: Principal Investigator LC-Triple Quadrupole Mass Spectrometer to Enhance LIfe Sciences Research NIH S10RR024605 Sep 20, 2007 - Role: Principal Investigator Impact of Non-canonical Decoding on the Proteome NIH R01GM085402 Aug 1, 2008 - Role: Principal Investigator MALDI TOF/TOF Mass Spectrometer for Imaging Thin Tissue Sections NIH S10RR025600 Apr 1, 2010 - Role: Principal Investigator ![]() ![]() Ultra-High Resolution Mass Spectrometer for Biomedical Research NIH S10RR028893 Apr 15, 2010 - Role: Principal Investigator Rapid ultra-sensitive three dimensional protein structure determination by mass s NIH R21RR032391 Aug 15, 2011 - Role: Co-Principal Investigator Rapid ultra-sensitive three dimensional protein structure determination by mass s NIH R21GM103531 Aug 15, 2011 - Role: Co-Principal Investigator Mass Spectrometry Imaging of Protein Gels NIH R01GM104610 Jul 23, 2012 - Role: Principal Investigator High-Resolution Ion Mobility Mass Spectrometer NIH S10OD018504 Aug 1, 2014 - Role: Principal Investigator All rights reserved.Circular Dichroism Spectrometer NIH S10OD028491 Jul 15, 2020 - Role: Principal Investigator In this review, we provide an overview of the pathogenic mechanisms of ceramides in NAFLD, discuss recent advances and challenges in pharmacological interventions targeting ceramide de novo synthesis, and propose some research directions in the field.Ĭeramide Ceramide de novo synthesis Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Sphingolipids Therapeutic target.Ĭopyright © 2022 Elsevier Inc. ![]() More importantly, pharmacological modulation of ceramide de novo synthesis in preclinical studies seems efficacious for the treatment of NAFLD. Emerging evidence indicates that ceramide production in NAFLD is predominantly attributed to activation of the de novo synthesis pathway of ceramides in hepatocytes. Ceramides have been shown to exacerbate NAFLD development through enhancing insulin resistance, reactive oxygen species production, liver steatosis, lipotoxicity and hepatocyte apoptosis, and eventually causing hepatic inflammation and fibrosis. Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its advanced form non-alcoholic steatohepatitis (NASH) may progress to cirrhosis and hepatocellular carcinoma.
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